Studies on a proteolytic enzyme system of the blood. I. Inhibition of fibrinolysin.
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چکیده
منابع مشابه
Studies on a Proteolytic Enzyme in Human Plasma
A fraction of globulin was prepared from human plasma which was deficient in prothrombin, thrombin, fibrinogen, plasma thromboplastin, and accelerator globulin. The preparation of globulin contained considerable potential proteolytic activity which could be activated by streptococcal fibrinolysin. This fraction of globulin accelerated the clotting of normal platelet-deficient plasma. However, t...
متن کاملStreptococcal Fibrinolysis: a Proteolytic Reaction Due to a Serum Enzyme Activated by Streptococcal Fibrinolysin
1. Methods for the preparation and partial purification of streptococcal fibrinolysin are described. 2. The lysis of fibrin clots in the presence of streptococcal fibrinolysin is associated with proteolysis of the fibrin. Digestion is due to an enzyme normally present in serum or plasma in an inactive state, which is activated by fibrinolysin. Fibrinolysin alone has no demonstrable proteolytic ...
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Although there is little doubt that more than one proteolytic enzyme occurs in plasma, plasmin (fibrinolysin) is the only such enzyme which has been definitely identified. Astrup and Permin,12 on the basis of differences in susceptibility to activation by streptokinase and fibrinokinase, have suggested that there are two precursors of fibrinolytic enzymes in human blood. They have designated th...
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The inhibitory effects of several steroids on G6PD activity using intact erythrocytes are reported. Incubation of whole blood with dehydroepiandrosterone (DHEA) resulted in 42% and 12% inhibition in the enzyme activity in the presence and absence of oxygen, respectively. Addition of epinephrine and/or aminophylline into the incubation medium caused further enzyme inhibition suggesting a po...
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Derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (PDC). The inhibition of transketolase, a thiamine requiring enzyme such as PDF, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (MNPB) is reported here. These studies indicate that the inhibitor binds to the enzyme at the active site. A two-step inhibition was observed, first th...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 29 8 شماره
صفحات -
تاریخ انتشار 1950